Monday, 3 August 2015

SIALIC ACID & ITS -VE CHARGE

SIALIC ACID

 Sialic acid, the cell membrane carbohydrate with its -ve charge is highly relevant at two sites:

 I. the RBC cell surface - same charge repel - influence        rouleaux formation - globulins of body infection response  remove these  charges - erythrocyte sedimentation rate  increases - useful in treating T.B.

 II. cells of the filteration slits in the glomeruli of nephrons      lose sialic acid charges in the process of inflammation and allow -ve charged  albumin to be  lost in the urine
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2 comments:

  1. Unknown3 August 2015 at 18:22

    sir,
    a pdf on the topic "Sialic Acid and Erythrocyte Surface Charge"
    http://www.jbc.org/content/237/6/1992.full.pdf.

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  2. Unknown6 August 2015 at 19:14

    Sir, point II that you've mentioned highlights the importance of membrane charges in albuminuria. We commonly perceive that increase in pore size is the only reason for proteinuria, but the role of Sialic acid is indeed crucial.

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